Structural and functional consequences of buserelin-induced enteric neuropathy in rat
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چکیده
منابع مشابه
Structural and functional consequences of buserelin-induced enteric neuropathy in rat
BACKGROUND Women treated with gonadotropin-releasing hormone (GnRH) analogs may develop enteric neuropathy and dysmotility. Administration of a GnRH analog to rats leads to similar degenerative neuropathy and ganglioneuritis. The aim of this study on rat was to evaluate the early GnRH-induced enteric neuropathy in terms of distribution of neuronal subpopulations and gastrointestinal (GI) functi...
متن کاملLong‑term follow‑up of buserelin‑induced enteric neuropathy in rats.
A few patients have been shown to develop severe abdominal pain and gastrointestinal dysmotility during treatment with gonadotropin‑releasing hormone (GnRH) analogs. A rat model of enteric neuropathy has been developed by administration of the GnRH analog buserelin to rats. Loss of enteric neurons and ganglioneuritis throughout the gastrointestinal tract has been described, without other histop...
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ژورنال
عنوان ژورنال: BMC Gastroenterology
سال: 2014
ISSN: 1471-230X
DOI: 10.1186/s12876-014-0209-7